News Archive 2022
Publication News: Frasor Lab
December 13th, 2022 - Congratulations to Dr. Frasor and her team for their latest article entitled "Identification of a novel ER-NFĸB-driven stem-like cell population associated with relapse of ER+breast tumors" published in the Breast Cancer Research journal. This work provides using single-cell RNA sequencing, we identified a novel quiescent stem-like cell population that is driven by ER and NFĸB in multiple ER+ breast cancer models. Moreover, we found that a gene signature derived from this stem-like population is expressed in primary ER+ breast tumors, endocrine therapy-resistant and metastatic cell populations and predictive of poor patient outcome. Read the full story here.
Publication News: Liew Lab
November 29th, 2022 - Congratulations Dr. Liew and his team for their latest article entitled "Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice" published in Nature Communications. In this work, we use studies in cells, mice and humans to demonstrate that scEMC10 is a previously unrecognized circulating inhibitor of adipose tissue thermogenic capacity and a potential therapeutic target for obesity and its complications. Read the full story here.
Publication News: Naba Lab
November 21st, 2022 - Congratulations to Dr. Naba and her team for their latest article entitled "MatrisomeDB 2.0: 2023 updates to the ECM-protein knowledge database" published in Nucleic Acids Research. In this manuscript, the team reports new developments to the MatrisomeDB, including its horizontal expansion to include ECM proteomic profiles of 24 new tissues, enhanced data visualization via peptide and post-translational modification mapping onto 2D domain-based representation and 3D structures of extracellular matrix and extracellular-matrix-associated proteins, and extensive cross-referencing to external resources to further facilitate the re-use of ECM proteomic studies by the scientific community. Read the full story here.
Publication News: Kazlauskas Lab
November 3rd, 2022 - Congratulations to Dr. Kazlaukas and his team for their latest article entitled “Hyperglycemia Promotes Mitophagy and Thereby Mitigates Hyperglycemia-Induced Damage” published in the American Journal of Pathology. This work provides insight on how cells within retinal blood vessels are endowed with a previously unappreciated ability to acquire resistance against the damaging effects of hyperglycemia, which drives development of complications such as retinopathy in patients with diabetes. This endogenous system that protects from the deleterious effects of diabetes is a plausible explanation of the long delay between the onset of diabetes and development of diabetic retinopathy.. Read the full story here.
Department News: Associate/Full Professor Search
September 27, 2022 - The Department of Physiology and Biophysics at the University of Illinois at Chicago (UIC) College of Medicine seeks outstanding candidates for tenured faculty positions at the Associate or Full Professor levels. To Apply visit the UIC job board here.
Publication News: Frasor Lab
September 26, 2022 - Congratulations to Dr. Frasor and her team for their latest article entitled “Emerging roles of ceramides in breast cancer biology and therapy” published in the International Journal of Molecular Sciences. This work provides insight on how ceramide synthesis and turnover is implicated in breast cancer biology and therapeutic modalities. Read the full story here.
Publication News: Naba Lab
June 17th, 2022 - Congratulations to Dr. Alexandra Naba for her contribution to the publication entitled "Systematic Analysis of Actively Transcribed Core Matrisome Genes Across Tissues and Cell Phenotypes" published in Matrix Biology. This study was conducted in collaboration with the Farach-Carson lab at the UT Houston, School of Dentistry and reports the pattern of expression of ECM genes across physiological systems.Read the full story here.
Publication News: Naba Lab
May 31st, 2022 - Congratulations to Dr. Alexandra Naba for her contribution to a perspective piece on the future of functional proteomics published in Molecular and Cellular Proteomics. Read the full story here.
Publication News: Frasor Lab
May 12th, 2022 - Congratulations to Dr. Jonna Frasor and her team for their latest publication entitled “Endocrine Therapy-Resistant Breast Cancer Cells Are More Sensitive to Ceramide Kinase Inhibition and Elevated Ceramide Levels Than Therapy-Sensitive Breast Cancer Cells”, published in Cancers. This study was conducted in collaboration with the Atilla-Gokcumen lab from University at Buffalo, and the Greene lab from University of Chicago reports a comprehensive sphingolipid profiling of endocrine therapy-sensitive and -resistant breast cancer cells and describes a unique ceramide sensitivity of endocrine therapy-resistant breast cancer cells.. Read the full story here.
Award News: Naba Lab
April 12th, 2022 - Congratulations to Dr. Alexandra Naba for receiving a 2022 Honoring Our Professors' Excellence (HOPE) award! Launched in 2015, the HOPE awards are presented by UIC Campus Housing to recognize faculty who have made a lasting impact on the lives of Housing residents.
Publication News: Rasenick Lab
April 4th, 2022 - Congratulations to Dr. Rasenick and his team for their latest article entitled “A novel peripheral biomarker for depression and antidepressant response” published in Molecular Psychiatry. This work provides insight on developing a depression biomarker. Read the full article here. Dr. Rasenick was also interviewed on NBC Chicago, WGN9 Chicago and Psychiatric News for his team's latest publication on a biomarker for depression.
Award News: 32nd Physiology Awards Night
March 31st, 2022 - Congratulations to all our award winners from the 32nd Physiology Awards Night. Dr. Jonathan Coloff was the recipient of the Philip K Hawley Distinguished Faculty Award. PhD candidates Anna Barque Falguera and Tung Nguyen won the Mark R Lambrecht and Kate Barany Graduate Student Awards, respectively. The John and Kathy Solaro Endowed Graduate Fellowship was awarded to MD/PhD Candidate Fred Lee. For more information about the awards may be found here.
Publication News: Frasor Lab
March 9th, 2022 - Congratulations to Dr. Semina for her latest paper entitled "Selective pressure of endocrine therapy activates the integrated stress response through NFκB signaling in a subpopulation of ER positive breast cancer cells", published in Breast Cancer Research. This study was conducted in collaboration with Dr. Huggins and Dr. Greene from the Department of Cancer at UIC, and Dr. Alarid from the Department of Oncology at UW-Madison. Read the full story here.